Around 400,000 women die every year from cardiovascular disease, making this the leading cause of death in American women. Among women with severe chest pain, 40-65% have no obstructive coronary artery disease, and receive no specific therapy. However, women have higher than expected risk for major adverse cardiac events.

This is a three-year clinical study being conducted to determine whether aggressive medication treatment will reduce women’s likelihood of dying, having a heart attack, stroke or being hospitalized. The results of this study will improve women’s cardiac health and quality of life.

Researchers will recruit 4,422 women who have chest pain, heart palpitations or shortness of breath which prompts referral for further evaluation by cardiac catheterization, or coronary angiogram within the previous 5 years. These women will be recruited around the nation and includes the Department of Veterans Affairs and active duty military hospitals and clinics.